The Biggest Mistake Students Make With DNA Replication

Have you ever stared at a DNA Replication problem and felt like you were reading another language? You aren't alone. Let's break down exactly why this trips up so many students.

Did you make this error?

• The Trap: confusing the leading and lagging strand
• The Proof: Read this scenario: DNA polymerase only reads 3' to 5'. Therefore, one strand is made continuously, while the other is made in backwards chunks (Okazaki fragments).

If your logic doesn't match the proof above, you've fallen for the trap. Erase it and start over.

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